How we work: quality and research standards

This page explains how Three Whole Health decides what goes into a product, how it is made, and what we will and will not say about it. We publish it so customers, clinicians and partners can hold us to it.

1. Ingredient evaluation

Before an ingredient is considered for a formula, we ask five questions:

1. Is there human evidence? We prioritize randomized controlled trials and systematic reviews in adults. Animal and in-vitro data can suggest a mechanism but never justify a claim on its own.
2. Does the evidence match the use case? A cranberry study on hospital catheter patients tells us little about healthy women with occasional urgency. We look for populations similar to our customers.
3. Is the studied form available? If trials used a standardized extract (for example, cranberry standardized to proanthocyanidins), we source that form, not a generic powder.
4. Is the studied dose practical? If an effective dose cannot fit in a daily serving, we do not include the ingredient in a token amount.
5. Is the safety profile acceptable? We review known interactions and contraindications and document them for the label and website.

The full walk-through is in How we evaluate a supplement ingredient.

2. Dosing and standardization

• Active doses are stated on the label. Where a blend is used, the blend weight is listed and the rationale is published on the brand page.
• Botanical extracts are specified by standardization marker where one exists (for example, 30% PACs for cranberry).
• We choose the lowest dose that the evidence supports for the intended effect. Yu Sleep's 0.9 mg melatonin is an example: enough to support the sleep signal, low enough to reduce next-day grogginess.

3. Manufacturing and testing

• All products are manufactured in the United States by contract manufacturers operating under 21 CFR Part 111 (current Good Manufacturing Practice for dietary supplements) in FDA-registered facilities.
• Raw materials are identity-tested on receipt. Finished batches are checked against specifications for identity, potency and contaminants before release.
• Batch records and certificates of analysis are retained by the manufacturer and available to us on request.
• Products are shipped from the United States and stored under controlled conditions.

4. Claims and labeling

Dietary supplements in the US may make structure/function claims (for example, "supports bladder control") but may not claim to diagnose, treat, cure or prevent disease. We follow this line strictly:

• We describe what an ingredient supports, and we say when results are gradual.
• We do not use words like "cure," "eliminate" or "reverse."
• Every claim carries the required FDA disclaimer, marked with a dagger (†) on this site.
• Testimonials, where used on brand sites, reflect individual experiences and are not presented as typical results.

5. Safety and interactions

Each brand page lists who should speak to a clinician before use. As a rule, we advise anyone who is pregnant, nursing, under 18, taking prescription medication or living with a diagnosed condition to get medical advice first. We do not position any product as a replacement for medical care.

6. Customer feedback loop

Support requests, refunds and reported side effects are reviewed regularly. Patterns feed back into labeling, education content and, where needed, reformulation. If you have had an unexpected reaction to one of our products, please tell us so we can record it.

Last reviewed: September 2026 by Ethan Techwell. See also our editorial policy and health disclaimer.